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Eric Schendel
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Policosanol Scientific Abstracts 1993
Prostaglandins Leukot Essent Fatty Acids 1993 Sep;49(3):695-7. Effect of policosanol on cerebral ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2. Arruzazabala ML, Molina V, Carbajal D, Valdes S, Mas R. Center of Natural Products, CNIC, Habana, Cuba.
Policosanol is a mixture of higher primary aliphatic alcohols, isolated from sugar cane wax, whose main component is octacosanol. Policosanol (25, 50 and 200 mg/kg) administered by the oral route not only significantly reduced serum thromboxane B2 (TXB2) levels but also, at 200 mg/kg significantly increased 6-keto-PGF1 alpha in Mongolian gerbils. Policosanol at 200 mg/kg significantly protected against cerebral ischemia induced by unilateral ligation of common carotid artery in Mongolian gerbils. In this experimental model, combined administration of ineffective doses of policosanol (25 mg/kg) and aspirin (ASA) (30 mg/kg) significantly protected animals indicating a synergism between them.
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Thromb Res 1993 Feb 1;69(3):321-7. Effects of Policosanol on platelet aggregation in rats. Arruzazabala ML, Carbajal D, Mas R, Garcia M, Fraga V. Department of Pharmacology and Toxicology, National Center of Scientific, Cubanacan, La Habana, CUBA.
Policosanol is the trivial name of a mixture of high molecular weight alcohols isolated from sugar cane, wherein octacosanol is the main component. The effects of Policosanol treatment on rat platelet aggregation were studied. Depending on the dose, Policosanol (5-20 mg/kg, perorally) inhibited the decrease in circulating platelet counts and collagen-induced malondialdehyde concentration in plasma. In rat clotted whole blood thromboxane B2 formation was inhibited by Policosanol (25 mg/kg). Policosanol (50-200 mg/kg, single doses) inhibited ADP-induced platelet aggregation in platelet-rich plasma, while lower doses (25 mg/kg) did not change responses to ADP significantly. However, rats treated with this dose (25 mg/kg) for 4 weeks showed a significant inhibition of platelet aggregation in PRP when a submaximal ADP concentrations was administered.
